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ST332 & ST409 Medical Statistics
创建日期：2024-07-10 15:28:23
所属分类：统计学statistics
标签： ST332
Medical Statistics

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ST332 & ST409 Medical Statistics:


Assignment [20%]

Background

Clinicians at University Hospitals Coventry & Warwickshire (UHCW) NHS Trust have studied  whether elevated levels (above 2.9 ng/mL) of a biomarker, carcinoembryonic antigen (CEA), after surgery (typically collected within 2 weeks following surgery) for patients undergoing

with colorectal cancer are prognostic for all-cause mortality. They collected data on co-morbidities – diagnosis of cardiovascular disease (CVD) prior to surgery, diagnosis of Chronic obstructive pulmonary disease (COPD) prior to surgery, in addition to smoking status which   is thought to affect CEA levels and age at the time of surgery.

Dataset

The R dataset crcsurg.RData contains synthetic data on 160 patients treated at UHCW NHS Trust over 15 years with a median follow-up of 5.7 years. The dataset only considers death as an outcome and contains the following variables and associated codes;

id (Patient ID number)

CEA (0=normal,1=elevated)

Smoker (0=no,1=yes at time of surgery)

Male (0=female,1=male)

Age (age in years at time of surgery)

CVD (0=none,1=CVD at time of surgery)

COPD (0=none,1=COPD at time of surgery)

pys (person-years follow-up since surgery)

dead (0=alive,1=dead)

Assignment Tasks

PART A [Maximum 5 pages – 15 marks]

Answer the following questions based on the crcsurg.RData dataset described above. Note it is not necessary to write a report – just answer the questions, but do not include R code or paste R output – marks will be lost for this.

1.   Undertake an Exploratory Data Analysis of the crcsurg.RData dataset, in

particular identify any covariates which may be potential confounders. [5 marks]

2.   Produce a summary table of the numbers of deaths and person-years data, based on the CEA level of patients. Calculate and interpret the associated Incidence Rate Ratio (IRR) and it’s 95% CI and P-value. [3 marks]

3.   Present and interpret an appropriate log-linear Poisson regression model that captures the effect of elevated CEA levels after adjusting for other relevant variables.

Carefully describe the model (defining any variables you refer to), how your model was chosen, how the results compare to those in Question 2, and any interesting/pertinent features. [5 marks]

4.   Your clinical colleagues suggest that a 10% relative increase in mortality due to

elevated CEA levels would be clinically important to detect. Describe how you would design a future study based on this information (and the results of your analyses in    questions 1 -3). [2 marks]

PART B [500 words maximum - 5 marks]

Based on your answers to PART A write a Press Release about the study for the University to make available to the media.

Marks will be awarded for;

•   Appropriate interpretation of the results in PART A

•    Discussion of strengths and limitations of the study

•    Use of non-technical language for an informed lay audience

•    Inclusion of an “anonymous” quote from you as “Researcher ”

• Discussion of potential next steps/further research

General Instructions

It is expected that PART A and B will be professionally presented (e.g. using LaTeX, WORD or R Markdown) and submitted on Moodle as a single pdf document. Do NOT put your name on the document or in the filename, please just use your student number. For PART B include a word count at the end of the Press Release. No appendices are allowed.

General questions about the assignment can be posted (anonymously if you wish) to the Discussion Forum on Moodle page for ST332, and these will be answered, questions emailed directly will not be answered.

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关键词一 关键词二 关键词三 关键词四 关键词五 和法规和的发更好的风格和 ECON 615 FINC 612 CSC148 COMP 639 ACCT 203 ACCT 211 PSYC 101 MTH2009 COMP52315 PSYCO 432 statistics MATH4063 11 xxx 1 MA1MSP MAST30028 MATH3888 CS341 EEE30002 ES2F5 MCD4160 CC0933 ECON 1101 MCHM3001 CHEM3118 COMMGMT 2511 COMP41280 STAT 631 24T1 IRE379 SENG365 ECON433 FIT3139 MATH4602 LING5621M FINS5516 ECON3208 MN2177 L2 SM EEET1415 Finance DS4023 COMP3004 7CCSMRTS K1S5B6 Stat230 CSCI4211 CSI2132 ECON30130 MAS6100 ENVS222 COM2107 INFO1112 STAT 4004 FIT2100 comp2022 COMP4691 Physics 307 Econ 659 probability CSCI316 fir29 CSCI203 COMP3160 COMP6714 INFO1113 Physics 7B Physics Photonics S203031 STAT2005 COMP90015 CSCI 2110 CSCC46 Information CSC477 COMP4650 Statistical COMP 346 COMP1017 ELEC340 MATH1007 Programming function STAT 244 CS 134 Java cse13s Math 108A FW20 ECON3389 CSE 130 Science 331 COMP9020 engineering COSC 445 CSE 5523 GAME2012 visualization MATH 235 Math 370 CSC343 COGS 108 EE524 COMP10200 STAT 416 3FK4 MSCI 311 ECON6113 ACC40700 EMESTER1 MAS8383 ECO 512 STAT 8310 CMN3102 MA577 CMPT 225 COMP0045 Methods Equations MATH 113 Math 3283W ICS-33 EN4302/ENT603 BIA B350F MA318 MTHM506 MECH 5315M ECONOMICS MAS8382 COM 2004 PX3142 XJEL 3662 STAT 231 MGT B399F PX4131 COM2108 30AM MSCI521 ECONM1015 ACFI304 GR5241 MATH10101 ECON 2070 COMS31900 EFIM20011 CSE 250B ACSE-5 STAT4207 SOFT2412 ELEC 331 AY2020 MSIN0209 FIT2094 CS 241L ST404 CS 411 3D CA3 INF4002 COMP3506 SIT718 CS 188 CS 170 MATH 138 CSE 251A CMT118 DATA5207 CMPT307 CMPT459 T1 PGEE11108 COSC 3P32 ME 163 MATH96007 7QQMM203 EE6227 BA 574 STA 4234 ECO206Y1Y ECO2008 MT2300 MATH 11158 CS 527 MACM 316 CSE474 2DI70 ISE 525 COMP3411 EMAT30007 7CCSMBDT MFIN704 MFIN704W21 MfIB ECE 438 CS 436 F36 CS5344 FE 621A FE621 TBA 612 ECM3151 ECMM422 MF1 MSIN0107 ESSMENT CS 5854 MFIT 5008 MIPS R4000 ENG5274 BU52018 ENG2079 BIOA02 STA2570 F0 INF553 STAT 440 STAT3008 COMP9417 COMP6451 6COM1042 BU52006 ST303 HW-1 CISC-235 CS 510 MATH3161 ECN 140 ECE391 Comp 3613 CVEN 9625 PRG455 UESTION 1 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MATH 239 QF5203 INFR08010 IT114105 FIT2093 ECON3124 ECON1195 MATH 337 STAT 3006 COMP202 COMP3130 MATH3609 COMP 250 CS6140 IEEE ELE00041I FIN40090 CIV 5899 MATH3066 IGNMENT MATH 2009 STAT3405 HIST 101 MATH 3281 CEGE0042 ICT532 LAB 7 LAB 5 MCO455 CSIT214 Q4 IFB104 A1 ECO220Y5Y DA5020 CMPSC473 FIN9007 DSCI553 MSCI534 COMP3308 CSE-112 CMPT 310 EE104 F 2C P20 ALY2010 BUSM060 STA258 ECO00030M R BIOSTAT 274 COS6012-B FIT3155 CMPUT 340 EC421 INFS4205 ECOM135 NATS 1740 COMP809 MBE 6005 STA465 CSSE2310 CIVL2700 DATA4700 CMPSC 473 ISE 529 CS5044 MAST30020 COMP2207 ENGG1001 COMP0046 FIT3165 STAT GR5241 MECH0007 vATHK1001 ANALYTIC ATHK1001 MATH352001 HW3 S1 BMAN 24662 COMP 636 Stat-461 STAT 302 STAT 2132 STAR534 ENG4137 CMP3752M CS3103 BISM3222 STA 135 ME155A IIMT3601 ECON3371 ECON 3371 HW4 FINA 5840 DT211C CTEC3902 MAT005 MATH2148 S261F Econ 332 MATH3734 MIS41270 7CCMFM13 SYST 664 CIS434 CENG10014 MT4111 MT4527 ECMM424 CMT219 Math 136 MATH 3120 COMP10002 MAST20009 MATH0058 BEEM117 ISYE 6420 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MATH20602 COMP532 MAS275 COMP5318 COMP4002 FIT5086 MAST20004 FIT3152 FIT5129 CIS2380 CS521 COMP 1005 EECMS CITS5501 ECE 462 ECON 6002 ENG 4051 CSC 648 CMT654 MECHENG 713 PHYS1002 AMME 2000 FP0060 DDES3200 MECHENG 743 BINF90002 FIT2081 ISYS90081 ELECTENG 722 BUS 360 ECOS3010 BUS2810 ETF2100 ENG2048 STAT5002 COMP2017 CEME 2003 MATS3004 COMP9319 PHYS1001 COMP5349 AMME2261 COMP-381 FIT3173 COSC2757 ENG4025 QBUS2820 COMP9414 MATH2021 EOSC118 MFIN6690 PMATH 321 CSE-141L MATH575A COMPSCI5002 COMP1511 management comp2123 FINS3616 COMP 3331 COMS30034 DTSC 71 AcF 702 AcF702 DTSC71 MAT021 ELE8083 ACFI213 EG-127J 127J FIT5163 FIT2001 ELE00113M CMT310 CS 245 ENGL 1101 MTH6115 EE497 CS 325 Math 124A MTH5130 MBA502 MGT 5380 ARCH 1261 F033800 20LLP109 ELE4009 FINANCIAL COMP3331 Computer ECE4179 20T3 COMP9311 COMP9311 UNSW MFIN6210 ACCT 5930 EE590 ENG2029 ECO100 SIT315 ACCT3610 COMP3600 STK2100 FIT2004 COMP30020 ACTL1101 Stat 101B BANA 200 COSC2473 ENGG1400 AI COMP90043 MMF 1914H PHYS 127 CS584 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