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IMM250F Past Midterm test
Choose the one best or most appropriate answer
Lectures 1, 2, 3 (Innate Immunity)
1. What was the important contribution to microbiology of Anton Van Leeuwenhoek in
the 1600s?
A. He was the first to observe microorganisms
B. He disproved the theory of spontaneous generation of microorganisms
C. He was the first to show that a disease could be caused by a microorganism
D. He was the first to describe the process of fermentation
Ans. A
2. Which of the following early contributors to the development of immunology is
paired up properly with his or her accomplishment?
A. Louis Pasteur: demonstrated that cowpox vaccination can protect from
smallpox
B. Paul Ehrlich: identified lymphocytes as the cells mediating adaptive immunity
C. MacFarlane Burnet: proposed the side-chain theory of antibodies which
suggested that multiple antigen receptors are expressed on immune cells
D. Robert Koch: developed techniques to grow pure bacterial cultures
Ans. D
3. In the late 1890s, ‘cellularists’ and ‘humoralists’ were intensively arguing about the
key components driving the immune response. What was a crucial finding that led
the humoralists to dominate the field in the following 50 years?
A. The demonstration of the Germ Theory of disease
B. The discovery that cell-free serum could transfer immunity from an immunized
animal to a non-immunized one
C. The discovery of the tuberculin reaction
D. The determination of the antibody structure
Ans. B
4. Phagocytes were discovered by:
A. Ilya Metchnikoff
B. Louis Pasteur
C. Emil von Behring
D. Robert Koch
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Ans. A
5. The clonal selection theory explains:
A. That one given lymphocyte expresses multiple antigen receptors with different
specificity
B. That antigens influence the generation of antigen receptors during lymphocyte
development
C. How the immune response to an antigen increases the number of lymphocytes
specific for that antigen
D. The increase in blood neutrophils observed during bacterial infections
Ans. C
6. The researcher that postulated the existence of ‘pattern recognition receptors’ on
innate cells was:
A. Susumu Tonegawa
B. Ilya Metchnikoff
C. Charles Janeway
D. Ralph Steinman
Ans. C
7. An example of a preformed chemical barrier is
A. Mucus
B. Lysozyme
C. Tight junctions in epithelial cells
D. Cilia in the respiratory tract
Ans. B
8. Which of the following does not describe defensins?
A. They disrupt pathogen membranes by penetrating them and disrupting their
integrity
B. They function as opsonins
C. They are amphipathic, that is they have hydrophobic and hydrophilic regions
D. They are contained in neutrophil granules
Ans. B
9. Why did Barry Marshall drink a pure culture of Helicobacter pylori?
A. To demonstrate the H. pylori is the cause of gastric cancer
B. To demonstrate an association between H. pylori infection and gastric ulcers
C. To demonstrate that gastric ulcers are caused by stress rather than bacterial
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infections
D. A and B are both correct
Ans. B